【摘要】 目的了解急性脑梗死患者不同性质颈动脉斑块与血清内脏脂肪素之间的关系,探讨内脏脂肪素在粥样硬化和脑梗死发生发展过程中的作用。方法纳入113例急性脑梗死患者和31例健康体检者,根据颈动脉彩超将脑梗死组分为无斑块(NP)组39例、稳定斑块(SP)组34例、不稳定斑块(VP)组40例3个亚组。测定健康体检者及急性脑梗死患者发病48 h内和第14 d血清内脏脂肪素水平,并进行相关分析。结果 VP组发病48 h内时内脏脂肪素水平高于SP组、NP组及对照组,14 d时高于NP组、对照组,差异均有统计学意义(P<0.05);SP组发病48 h内内脏脂肪素水平高于NP组、对照组,差异均有统计学意义(P<0.01)。血清内脏脂肪素与体质指数(r=0.190)和血糖(r=0.215)呈正相关。结论内脏脂肪素可能在动脉粥样硬化、斑块形成及脑梗死的发生发展中起重要作用。更多还原

【Abstract】 Objective To investigate the relationship between carotid artery plaque of different characteristics and visfatin in patients with cerebral infarction,and to explore the action of visfatin in atherosclerosis and the development of cerebral infarction. Methods Totally 113 patients with acute cerebral infarction and 31 healthy persons were enrolled. According to the characteristics of carotid artery ultra- sonography the patients were sub- divided as no- plaque( NP)( n = 39),stable plaque( SP)( n =34) and variable plaque( VP)( n = 40) groups. The serum visfatin levels of all the subjects were measured with ELISA within 48 hours of onset and the 14th day,and the correlation between visfatin and carotid artery plaque was analyzed. Results The serum level of visfatin within 48 hours of onset was significantly higher in the VP group than those in the rest 3 groups( P <0. 05),and the visfatin level was higher in the SP group than those in the NP and control groups,and the 14th day was significantly higher than NP and control groups( P < 0. 01). The serum visfatin level was correlated positively with the body mass index( r =0. 190) and the level of fasting blood glucose( r =0. 215). Conclusion Visfatin may play a critical role in the development of carotid atherosclerosis,plaque and cerebral infarction.更多还原