【摘要】 目的观察血液灌流对原发性干燥综合征(pSS)患者的临床疗效。方法选取2012-02-25—06-30在我院风湿免疫科住院的13例pSS活动期患者,均行锁骨下深静脉置管后,采用肝素抗凝,进行血液灌流治疗,每次灌流时间为2～3 h,1～2次/周,共灌流3次。检测并比较患者血液灌流前后的红细胞沉降率(ESR)、C反应蛋白(CRP)、类风湿因子(RF)、免疫球蛋白G(IgG)、免疫球蛋白A(IgA)、免疫球蛋白M(IgM)和外周血CD3+、CD4+、CD8+T细胞百分比及CD4+/CD8+。结果血液灌流后,pSS患者ESR、RF、IgG、IgA及外周血CD4+T淋巴细胞百分比、CD4+/CD8+较血液灌流前降低,CD3+、CD8+T淋巴细胞百分比较血液灌流前升高,差异有统计学意义(P<0.05)。血液灌流后,10例患者口干症状减轻,9例患者关节痛明显改善,7例患者眼干减轻。结论血液灌流能缓解pSS患者的临床症状,改善实验室检查指标。更多还原

【Abstract】 Objective To investigate the clinical effect of hemoperfusion in treating patients with primary Sjogren′s syndrome(pSS).Methods A total of 13 patients with active pSS in rheumatology department of our hospital between 2012-02-25 and 06-30 were selected.After subclavian vein catheterization,heparin anticoagulation and hemoperfusion treatment were adopted,2~3 h perfusion time at a time,1~2 times once a week,and 3 times perfusion in all.Laboratory indexes were detected and compared,such as erythrocyte sedimentation rate(ESR),C-reactive protein(CRP),rheumatoid factor(RF),immunoglobulin G(IgG),immunoglobulin A(IgA),immunoglobulin M(IgM),peripheral blood CD3+,CD4+,CD8+ T lymphocytes percentage and CD4+/CD8+.Results Compared with pre-hemoperfusion,the level of plasma ESR,RF,IgG,IgA and peripheral blood percentage of CD4+T lymphocytes and CD4+/CD8+ lymphocytes decreased,and the percentage of CD3+,CD8+ T lymphocytes in peripheral blood were improved significantly after hemoperfusion(P<0.05).After hemoperfusion treatment,the clinical symptoms of the pSS patients were improved remarkably,including 10 patients with relief of dry mouth symptom,9 patients with significant improvement in joint pain and 7 patients with relief of dry eyes symptom.Conclusion Hemoperfusion can relieve clinical symptoms in patients with pSS and improve laboratory indexes.更多还原