【摘要】 目的探讨彩色多普勒超声检测非酒精性脂肪性肝病(NAFLD)患者血流动力学变化的应用价值。方法选择我院2011年1月—2012年2月收治的住院NAFLD患者共90例,根据肝脏脂肪浸润程度将患者分为轻度组、中度组和重度组,每组30例;选择同期我院门诊体检健康者30例为对照组。采用彩色多普勒超声检测各组门静脉最大速度(PPVV)及平均速度(MPVV)、肝动脉阻力指数(HARI)、肝中静脉脉冲多普勒频谱特征。结果各组肝中静脉脉冲波形构成比较,差异有统计学意义(χ2=28.342,P<0.01)。对照组PPVV为(21.8±2.6)cm/s,轻度组为(19.6±2.4)cm/s,中度组为(17.6±2.2)cm/s,重度组为(15.8±2.1)cm/s,差异有统计学意义(F=36.82,P<0.05);4组对象MPVV分别为(20.4±1.5)cm/s、(16.6±2.4)cm/s、(16.2±2.9)cm/s、(13.7±0.7)cm/s,差异有统计学意义(F=54.28,P<0.05);HARI分别为(0.79±0.03)、(0.77±0.04)、(0.73±0.03)、(0.71±0.04),差异有统计学意义(F=32.00,P<0.05)。结论应用彩色多普勒超声检测NAFLD患者血流动力学变化,可反映肝脏脂肪变性程度及其进程,经济安全,操作简单,临床应用价值较好。更多还原

【Abstract】 Objective To investigate the value of Doppler ultrasound in the assessment of the changed hemodynamics of patients with non-alcoholic fatty liver disease(NAFLD).Methods Ninety NAFLD patients who were treated in our hospital from January 2011 to February 2012 were selected as subjects and divided into mild(n=30),moderate(n=30),and severe(n=30)groups;And 30 healthy people who were received physical examination at the same time were chosen as control group.The peak and mean portal vein velocity(PPVV and MPVV),hepatic artery resistance index(HARI),and spectral waveform of the middle hepatic vein were measured with Doppler ultrasound.Results The spectrum waveforms in the middle hepatic vein showed significant difference(χ2=28.342,P<0.01)in each group.The PPVV was(21.8±2.6)cm/s,(19.6±2.4)cm/s,(17.6±2.2)cm/s,and(15.8±2.1)cm/s in the control,mild,moderate,and severe groups,with significant difference(F=36.82,P<0.05).The MPVV was(20.4±1.5)cm/s,(16.6±2.4)cm/s,(16.2±2.9)cm/s,and(13.7±0.7)cm/s,respectively,with significant difference(F=54.28,P<0.05).The HARI was(0.79±0.03),(0.77±0.04),(0.73±0.03),and(0.71±0.04),respectively,with significant difference(F=32.00,P<0.05).Conclusion Coler Doppler ultrasonography is a simple and cost-effective approach to detect the change of hemodynamics in NAFLD patients.更多还原