【摘要】 目的探讨冠心病合并2型糖尿病患者非酒精性脂肪性肝病(NAFLD)的发病率和危险因素。方法对280例冠状动脉造影诊断为冠心病的2型糖尿病患者入院期间均行空腹肝胆超声检查以确诊NAFLD,分析NAFLD的危险因素。结果本组NAFLD的发病率为63.6%(178/280)。NAFLD的发生率随着冠状动脉病变程度加重而增加(χ2趋势=6.148,P=0.01)。中重度NAFLD患者的多支病变发生率明显多于轻度者,差异有统计学意义(χ2=10.317,P<0.01)。多因素Logistic回归分析显示,冠心病多支病变和左主干病变是NAFLD的独立危险因素。结论冠心病合并2型糖尿病患者NAFLD发病率较高,冠状动脉多支病变、左主干病变是其发生NAFLD的重要危险因素。更多还原

【Abstract】 Objective To investigate the incidence and risk factors of NAFLD in coronary artery disease with type 2 diabetes mellitus patients undergoing coronary angiogram.Methods 280 patients with coronary artery disease in type 2 diabetes mellitus who underwent coronary angiogram were enrolled into this study.All patients had ultrasound screening for fatty liver.Results Among 280 recruited patients,178(63.6%) had fatty liver by ultrasonography.The incidence of NAFLD increased with the severity of coronary artery lesions(χ2trend=6.148,P=0.01).Multi-vessel lesions in moderate to severe NAFLD was higher than the mild level(χ2=10.317,P<0.01).By multivariable Logistic regression analysis,multi-vessel lesions or stenosis of left main stem were risk factor in NAFLD patients with coronary heart disease in diabetes mellitus.Conclusion In coronary artery disease patients with diabetes mellitus,multi-vessel lesions and stenosis of left main stem are the important risk factors for NAFLD occurrence.更多还原