【摘要】 目的研究雌激素及血管紧张素转化酶(ACE)与绝经后女性冠心病发生的相关性。方法纳入既往曾发生胸痛胸闷症状的绝经后女性患者106例,根据冠脉造影结果分为冠心病组(n=51)和非冠心病组(n=55),采用放射免疫分析法测定雌二醇(E2),紫外线分光光度法测定血管紧张素转化酶(ACE)水平,比较两组有无差异。结果冠心病组平均年龄(64.37±1.12)岁,非冠心病组平均年龄(63.16±1.00)岁,两组年龄无统计学差异(P>0.05)。冠心病组E2水平明显低于非冠心病组[(19.31±1.20)pg/mlvs.(31.70±4.25)pg/ml,P<0.05],ACE水平则高于非冠心病组[(67.96±6.59)U/mLvs.(58.38±5.31)U/mL,P<0.05],同时雌激素与血管紧张素转化酶水平呈负相关(r=-1.652,P<0.05)。结论绝经后女性冠心病的发生可能与E2水平较低和ACE水平升高有关。更多还原

【Abstract】 Objective To study the correlation between estrogen (E2) or angiotensin converting enzyme (ACE) and occurrence of coronary heart disease (CHD) in postmenopausal women. Methods The postmenopausal patients (n=106) with the past symptoms of angina pectoris (chest pain and tightness) were chosen and divided into CHD group (n=51) and non-CHD group (n=55) according to the results of coronary angiography (CAG) The level of E2 was detected by using radioimmunoassay, and level of ACE was detected by using ultraviolet spectrophotometry. The results were compared between two groups. Results The average age was (64.37±1.12) in CHD group and (63.16±1.00) in non-CHD group (P>0.05) . The level of E2 was significantly lower [(19.31±1.20) pg/ml vs . (31.70±4.25) pg/ml, P<0.05] and level of ACE was higher [(67.96±6.59) U/mL vs . (58.38±5.31) U/mL, P<0.05] in CHD group than those in non-CHD group. At the same time, the level of E2 was negatively correlated to level of ACE (r=-1.652, P<0.05) . Conclusion The incidence of CHD may be related to the low concentration of E2 and ACE increased in postmenopausal women.更多还原