【摘要】 目的比较动态血糖监测下超短效与短效胰岛素经胰岛素泵皮下输注治疗糖尿病的疗效。方法将2型糖尿病患者40例分为A组和B组,每组各20例,A组经胰岛素泵皮下输入超短效胰岛素治疗2周。B组经胰岛素泵皮下输入短效胰岛素治疗2周。两组患者治疗前后均佩带动态血糖监测系统(CGMS)3d。观察两组治疗前后空腹血糖(FPG)、午餐后2h血糖及睡前血糖、达标时间与胰岛素用量,血糖均值、血糖值标准差、血糖≥10.0mmol/L时间百分比,血糖≤3.9 mmol/L时间百分。结果两组治疗前及治疗后FPG、午餐后2h血糖及睡前血糖比较,差异均无统计学意义(P>0.05)。A组达标时间及胰岛素用量均低于B组,差异有统计学意义(P<0.05)。治疗2周后,A组及B组治疗后的血糖均值、血糖标准差及血糖≥10.0mmol/L时间百分比均低于治疗前,差异有统计学意义(P<0.05)。A组及B组治疗后血糖≤3.9 mmol/L时间百分比较治疗前明显增多,差异有统计学意义(P<0.05)。A组治疗后血糖均值、血糖标准差、血糖≤3.9mmol/L时间百分比均低于B组,差异有统计学意义(P<0.05)。A组治疗后血糖≥10.0mmol/L时间百分比与B组比较,差异无统计学意义(P>0.05)。结论超短效胰岛素比短效胰岛素降糖效果更好、更稳,低血糖发生时间更少。采用CGMS观察疗效较指血血糖监测更准确。更多还原

【Abstract】 Objective To evaluate the efficacy of continuous subcutaneous continuous insulin lispro and humulin on the treatment type2 diabetes mellitus(DM) by continuous glucose monitoring system(CGMS).Methods 40 DM patients were divided into A and B groups randomly.A group had 20 cases which were given continuous subcutaneous continuous insulin lispro and B group had 20 cases which were given continuous subcutaneous continuous insulin humulin for two weeks.The levels of blood sugar at empty stomach and 2 hours after lunch and before sleep were detected before and after treatmate.The daily blood glucose profiles were observed before treatment and after treatment for 2 w by CGMS.Results The levels of blood sugar at empty stomach and 2 hours after lunch and before sleep were no significant differences after treatmate in both groups(P>0.05).After treatment,average glycemic values、standard deviationof glycemic values and the percentage of time spent in glycemic lower 3.9 mmol/L in A group were lower than those in B group.There were significant differences(P<0.05).The percentage of time spent in hyperglycemic above 10 mmol/L were no significant differences after treatmate in both groups(P>0.05).Conclusion The therapeutic effect of A group was superiority to that in B group.更多还原