【摘要】 [目的]喹啉类化合物具有广泛的生物活性,寻找更好的高活性化合物并进行先导结构优化。[方法]以取代的2,3-二甲基-4-羟基喹啉作为中间体,利用中间体衍生化方法进行合成。[结果]合成了喹啉酯、喹啉醚及喹啉胺3类新化合物,其结构得到了NMR的表征和确认。[结论]生测结果表明,部分目标化合物对水稻稻瘟病、小麦白粉病有较好的防效。更多还原

【Abstract】 Quinolines possess a broad spectrum of biological activity,the purpose of this article is to search for better compound with high activity and then to carry out optimization around the lead structure.[Methods] The intermediate derivatization methods was adopted to synthesize the target compounds based on 2,3-dimethyl-4-hydroxy quinoline as intermediates.[Results] Quinoline ester,quinoline ether and quinoline amines were synthesized in this paper.All structures of the synthesized compounds were confirmed by 1H NMR.[Conclusions] Preliminary bioassay indicated that,some synthesized compounds have good fungicidal activities against Rice Blast and Wheat powdery mildew.更多还原