【摘要】 改进了除草剂氟噻草胺的合成工艺:以氨基硫脲为原料,与三氟乙酸环合生成2-氨基-5-三氟甲基-1,3,4-噻二唑,再经重氮化反应生成2-氯-5-三氟甲基-1,3,4-噻二唑,最后与2-羟基-N-(4-氟苯胺)-N-(1-甲基乙基)乙酰胺反应,经后处理得氟噻草胺。该工艺路线流程短、产品效率高、含量高、三废少且反应条件温和,易于操作和控制,适合工业化生产。文章还对主要因素的影响进行了实验与分析。更多还原

【Abstract】 The paper studied on the flufenacet’s synthesis process, which is greatly improved: aminothiourea is taken as the raw materials, cyclized with trifluoroacetic acid to generate 2-amino-5-trifluoromethyl-1, 3, 4-thiadiazol, then the product 2-chloro-5-trifluoromethyl-1, 3, 4-thiadiazole is got through diazotization, finally reacted with 2-hydroxy-N-(4-fluorophenyl)-N-(isopropyl) acetamide to generate flufenacet after treatment. The route is suitable for the industrial production with the characteristics of short process, high efficacy and yields, mild reaction condition, which is conducive to operate and control.更多还原