【摘要】 目的:了解青岛市区前列腺癌发病的危险因素,为前列腺癌的科学防治提供理论依据。方法:在青岛市市立医院开展一项病例对照研究(1∶2配对),匹配条件为年龄、性别、民族和居住地类型相同。调查以面谈为主,辅以调查病历记录,采用条件Logistic回归法分析数据。结果:收到有效调查问卷258份,前列腺癌、BPH和其他前列腺疾病患者各86份,以其他疾病作为对照,家族中有恶性肿瘤患者前列腺癌的风险是无亲属患恶性肿瘤者的2.58倍;首次遗精年龄≤14岁者患前列腺癌的风险是≥18岁者的2.27倍;而首次性交年龄在25～30岁者是前列腺癌的保护因素,OR=0.76;35岁以前性生活频率≥4次/周与手淫≥3次/周者患前列腺癌风险明显增高,OR分别为2.57、2.30;吸烟和饮酒者前列腺癌发病风险亦增高,饮酒超过10年者尤为显著(OR=2.83)。结论:肿瘤家族史、首次遗精年龄较早、35岁前性生活频繁、手淫频繁、饮酒超过10年以上(乙醇≥150 g/d)均为前列腺癌的危险因素。更多还原

【Abstract】 Objective:To investigate the risk factors of prostate cancer in urban Qingdao and provide some theoretical evidence for the scientific prevention and treatment of the disease.Methods:We performed a hospital-based matched case-control study in Qingdao Municipal Hospital.The cases and controls were matched in age,gender,nationality and the place of residence.All the subjects were interviewed face to face in the hospital using a questionnaire,and the data analyzed by the conditional logistic regression method.Results:According to the 258 valid questionnaires collected,the prostate cancer risk was significantly higher in the cases with a family history of cancer than in those without(OR=2.58),and so was it in the men with the first spermatorrhea at the age of ≤15 years than in those at the age of ≥18 years(OR=2.27).A decreased risk of prostate cancer was found among the men with the first experience of sexual intercourse between 25 to 30 years of age(OR=0.76).An increased risk was shown in those with sexual intercourses ≥4 times per week before 35 years old(OR=2.57),masturbations ≥3 times per week(OR=2.30) and a drinking history(alcohol ≥150 g/d) of ≥10 years(OR=2.83).Conclusion:Positive family history of cancer,earlier age of the first spermatorrhea,sexual intercourses ≥4 times per week before 35 years old,frequent masturbations,and heavy drinking for more than 10 years are risk factors for prostate cancer.更多还原