【摘要】 前列腺癌(PCa)是老年男性常见疾病,其发病率居西方国家男性恶性肿瘤第2位。近年来,我国的发病率呈上升趋势。肿瘤的转移是导致前列腺癌患者死亡的主要原因。在肿瘤的发生发展过程中,浸润区肿瘤细胞与其微环境相互作用,经历上皮-间质转化(EMT),最终出现远处转移。因此研究EMT在前列腺癌发生发展中的作用,对前列腺癌治疗有重要意义。本文主要参考近3年相关的文献,以治疗靶点为方向,对促进前列腺癌EMT的因素,作一综述。更多还原

【Abstract】 Prostate cancer(PCa) is a common disease in elderly men,its incidence ranking the second among all malignancies in males in Western countries and increasing in China in the last decade.Tumor metastasis is the main cause of death of PCa patients.In the development and progression of tumor,the tumorous cells in the infiltration area interact with their microenvironment,undergo epithelial-mesenchymal transition(EMT) and consequently cause distant metastases.So to study the role of EMT in the development and progression of tumor is of great significance for the treatment of PCa.This article reviews the relevant literature of the last 3 years and gives an overview of the factors affecting EMT in prostate cancer,aiming at a therapeutic target.更多还原