【摘要】 目的:探讨小剂量他达拉非降阶梯治疗对心因性勃起功能障碍的疗效。方法:采用勃起功能国际指数问卷(IIEF-5)、勃起硬度分级评分(EHS)。将门诊诊断为心因性勃起功能障碍共84例患者随机分小剂量他达拉非降阶梯治疗组(观察组,n=42)、按需治疗组(对照组,n=42)治疗2个月,进行治疗前后及组间对比评分。结果:对照组5例失访共79例完成观察研究。两组治疗后IIEF-5评分、EHS较治疗前均明显提高。观察组、对照组治疗ED有效率分别达95.2%、86.5%,与对照组相比,观察组有更高的有效率以及依从性(P<0.05)。结论:他达拉非对心因性勃起功能障碍具有良好作用,小剂量他达拉非降阶梯治疗优于按需治疗。更多还原

【Abstract】 Objective: To investigate the effect of low-dose daily de-escalatory administration of tadalafil on psychological erectile dysfunction(ED).Methods: We randomized 84 psychological ED patients into an observation and a control group of equal number to receive low-dose daily de-escalatory administration and on-demand medication of tadalafil,respectively,both for 2 months.We compared the scores on IIEF-5 and erection hardness(EHS) between the two groups before and after the treatment.Results: The treatment and follow-up were accomplished for 79 cases,with 5 withdrawals in the control group.The IIEF-5 and EHS scores were remarkably improved in both the observation and control groups after treatment.The rate of therapeutic effectiveness was significantly higher in the observation group than in the control(95.2% vs 86.5%,P<0.05).Conclusion: Low-dose daily de-escalatory administration of tadalafil is highly effective and even better than on-demand medication of tadalafil for psychological ED.更多还原