【摘要】 目的探讨联合检测甲胎球蛋白(AFP)、糖抗原125(CA125)、糖抗原19-9(CA19-9)在肝细胞癌(HCC)与肝脏转移瘤鉴别诊断中的价值。方法检测93例患者的血清AFP,CA125和CA19-9浓度,其中HCC组45例,肝脏转移瘤组38例,良性肝病组10例。结果①良性肝病组三种标志物均阴性,HCC组AFP阳性率明显高于肝脏转移瘤组,且联合检测AFP、CA125、CA19-9阳性率高达88.9%,明显高于AFP单项检测(P<0.05);②HCC组血清CA19-9和CA125阳性率分别为57.8%和77.8%,联合检测CA19-9、CA125阳性率明显高于肝脏转移瘤组(P<0.05)。结论 AFP仍是诊断肝细胞癌的主要血清学肿瘤标志物,联合检测AFP、CA125、CA19-9可明显提高HCC的敏感性。更多还原

【Abstract】 Objective To explore the differential diagnosis value of combination detection of serum alpha-fetoprotein( AFP),Carbohydrate antigens 125( CA125) and Carbohydrate antigens 19-9( CA19-9) between hepatocellular carcinoma( HCC) and liver metastases. Methods The level of serum AFP,CA125 and CA19-9 were detected in 95 patients,including 45 cases of HCC,38 cases of liver metastases,and 10 cases of benign liver disease. Results ① Three markers in patients with benign liver disease were all negative. The positive rate of serum AFP was increased significantly( P < 0. 05) in patients with HCC compared with liver metastases,and the positive rate of joint detection of AFP,CA125 and CA19-9 was 88. 9%,which were significantly( P < 0. 05) higher than AFP detection, ② The positive rate of serum CA19-9 and CA125 were 57. 8% and 77. 8%,respectively,and the positive rate of detection of CA19-9 and CA125 significantly( P < 0. 05) higher in patients with HCC than those of patients with liver metastases. Conclusion AFP is still one of the most important tumor markers in the diagnosis of HCC. Combined detection of serum AFP,CA125 and CA19-9 can significantly improve the sensitivity of HCC.更多还原