探讨超声造影定量分析技术观察糖尿病肾病(Diabetic nephropathy,DN)的肾功能损害的临床价值。方法:选取临床已确诊的Mogensen分期为Ⅲ期、Ⅳ期的DN患者16例,其中Ⅲ期为早期DN组,Ⅳ期为临床期DN组,各8例,另选年龄、身高、体质量相匹配的健康志愿者8例为对照组。利用QLAB定量分析软件的时间-强度曲线(Time-intensity curve,TIC)观察感兴趣区(Region of interest,ROI)超声造影定量灌注参数,并统计3组间的差异。结果:早期DN组与对照组比较,肾皮质灌注曲线下面积(Area under curve,AUC)增加、峰值强度(Derived peak intensity,DPI)降低的差异有统计学意义(P<0.05)。临床期DN组与对照组比较,肾血流灌注的达峰时间(Time to peak,TTP)延长、DPI降低、AUC减少、曲线上升支斜率增加(Slope rate of ascending curve,A)的差异有统计学意义(P<0.05)。在早期DN组与对照组、临床期DN组与对照组间的曲线下降支斜率(Slope rate of descendi...
【英文摘要】
Absract: Objective: To probe the clinical value of quantitative analysis of contrast-enhanced ultrasound on diabetic nephropathy(DN).Methods: Eight patients of clinical definite stage Ⅲ and Ⅳ DN were selected as early period group and clinical period group respectively,meanwhile 8 healthy volunteers with age,height,weight matched were included as control group.We observed the quantitative perfusion parameters of time-intensity curve(TIC) on QLAB quantitative analysis software,and the statistical differences...
| 
推荐 
点击下列相关研究机构和相关文献作者，可以直接查到这些机构和作者被《中国知识资源总库》收录的其它文献，使您全面了解该机构和该作者的研究动态和历史。
