【摘要】 目的观察盐酸纳洛酮对急性颅脑损伤患者临床各项指标的影响。方法选取我院2010年3月至2012年5月收治的52例急性颅脑损伤患者的临床资料,观察组(常规治疗+盐酸纳洛酮治疗)31例,对照组(常规治疗)21例,比较两组患者的临床各项指标的改善情况。结果治疗第7天,观察组患者的血ET水平、GCS评分情况以及EEG检测异常率等指标变化情况均优于对照组,两组比较差异具有统计学意义(P<0.05);观察组的中、前部动脉血流情况、大脑后动脉以及基底动脉的血流情况同对照组相比有显著改善,差异有统计学意义(P<0.05)。结论及时应用盐酸纳洛酮治疗急性颅脑损伤,对改善患者的病情、降低颅内压、减少病死率等均具有十分重要的意义。更多还原

【Abstract】 Objective To investigate the effect of naloxone hydrochloride on the indexes of patients with acute brain injury.Methods Clinical data of 52 acute brain injury patients were analyzed,including 31 patients in the observation group(treated with naloxone hydrochloride),and 21 patients in the control group(conventional treatment),the clinical indexes of the two groups were compared.Results In observation group,GCS score was obviously improved,the level of ET in plasma was reduced;brain vasospasm incidence rate and abnormal rate of EEG was lower than those in control group.As a result,the detecting indices in treating group were superior to those in the control group(P<0.05).Conclusion Naloxone hydrochloride therapy for acute brain injury is very important to improve the patient′s condition and reduce intracranial pressure,and it is worthy of widely clinical applications.更多还原