【摘要】 目的:通过探讨缺血性中风中医辨证分型与血浆TXB2及6-keto-PGF1α之间的关系,力图进一步揭示缺血性中风各证型的本质及演变规律,筛选出能反映中医证候客观化的敏感指标。方法:以泸州地区200名急性缺血性中风患者作为研究对象,辨证分型,分组进行对比研究。结果:缺血性中风患者TXB2和6-keto-PGF1α存在明显直线相关和回归关系。缺血性中风不同中医证型组TXB2与6-keto-PGF1α值均成明显直线相关和回归关系:风痰瘀血闭阻脉络组直线回归方程为Y(TXB2)=691.79+0.56X(6-keto-PGF1α),(R=0.417,P=0.003<0.01,回归方程成立);风痰上扰痰热腑实组直线回归方程为Y(TXB2)=401.51+0.58X(6-keto-PGF1α),(R=0.491,P=0.000<0.01,回归方程成立);气虚血瘀组直线回归方程为Y(TXB2)=150.10+1.11X(6-keto-PGF1α),(R=0.638,P=0.001<0.01,回归方程成立);阴虚风动组直线回归方程为Y(TXB2)=184.19+0.91X(6-ketoPGF1α),(R=0.638,P=0.000<0.01,回归方程成立)。结论:TXB2及6-keto-PGF1α可以作为缺血性中风中医证型的客观化指标之一。更多还原

【Abstract】 Objective: To investigate the relationship between of TCM syndromes of ischemic stroke and endothelial cell secretory function, in a bid to reveal the nature and effective sensitive indicator of the TCM syndrome types. Methods:200 patients with acute ischemic stroke in Luzhou city were differentiated according to their symptoms and signes into 4 TCM syndrome types:wind-phlegm with blood stasis and vessel block syndrome(type A),upward disturbance of wind-phlegm and excess phlegm and heat of fu-viscera syndrom(type B),Qideficient and blood stasis syndrome(type C) and Yin deficient and wind-activation syndrome(type D),and comparatively studied. Results: There were significant linear and regressive correlations between TXB2 and 6-keto-PGF1α in 4 types of ischemic stroke syndrome.The regression equation in type A, B, C, D were Y(TXB2)=691.79+0.56X(6-keto-PGF1 α),(R=0.417,P=0.003<0.01), Y(TXB2)=401.51+0.58X(6-keto-PGF1α),(R=0.491,P=0.000<0.01), Y(TXB2)=150.10+1.11X(6-keto-PGF1 α),(R=0.638,P=0.00<0.01), and Y(TXB2)=184.19+0.91 X(6-keto-PGF1 α),(R=0.638, P=0.000<0.01,) respectively. Conclusion: TXB2 and 6-keto-PGF1α can be used as the objective indicators for the differential TCM syndrome types of ischemic stroke.更多还原