【摘要】 目的观察急性心肌梗死(acute myocardial infarction,AMI)患者早期微量蛋白尿(microalbuminuria,MA)的自然变化规律,并对其进行临床相关性研究。方法对连续入选的602例胸痛患者进行研究。所有患者于住院当日、第3天和第7天检查尿微量蛋白肌酐比值,大于或等于300μg/mg定义为MA阳性。同时检查N末端脑钠肽前体(N-terminal B-type brain natriuretic peptide,NT-proBNP)。结果 AMI后MA呈动态变化,心肌梗死后当天即开始升高,第3天达峰,第7天时下降。三个时间点MA阳性率分别为35.9%、50.8%和15.8%。MA的水平和心肌梗死的面积明显相关(r=0.56,P<0.05)。结论 AMI后MA反应性升高,且呈动态变化,其变化与梗死面积和心功能相关。更多还原

【Abstract】 Objectives To observe the dynamic changes of microalbuminuria(MA) after acute myocardial infarction(AMI) in patients.Methods Totally 602 patients with pectoralgia were included in the study.Urinary albumin excretion,expressed as microalbumin / creatinine ratio,was measured at day 1,3 and 7.The value of this ratio not less than 300 μg / mg was defined as MA positive.Also N-terminal pro-B-type brain natriuretic peptide(NT-proBNP) was tested.Results MA significantly elevated at day 1,climaxed at day 3,and declined at day 7 after AMI.The positive rates of MA at these time points were 35.9%,50.8% and 15.8%.There was a strong relation between MA and infarction areas(r=0.56,P<0.05).Conclusions There is a dynamic change in microalbuminuria in patients after AMI,which is related to infarction areas and cardiac function.更多还原