【摘要】 目的:检测三组散发型白癜风患者治疗前后外周血CD4+/CD8+T细胞比值及CD4+CD25+调节性T细胞水平,评价三种治疗方案对散发型白癜风免疫功能的影响。方法:将76例患者随机分为三组:治疗①组:单用吡美莫司治疗;治疗②组:吡美莫司联合中药方剂治疗;治疗③组:吡美莫司联合白芍总苷治疗,用流式细胞仪对三组患者治疗前后外周血CD4+/CD8+T细胞比值及CD4+CD25+调节性T细胞水平进行检测。结果:与治疗前相比,治疗后三组散发型白癜风患者外周血中CD4+/CD8+T细胞比值和CD4+CD25+调节性T细胞水平均升高,差异均有统计学意义(P值均<0.05)。吡美莫司联合白芍总苷组变化水平高于单用吡美莫司组,但低于联合中药方剂组,差异均有统计学意义(P<0.05)。结论:三种方案均能不同程度的提高散发型白癜风患者外周血CD4+/CD8+T细胞比值及CD4+CD25+调节性T细胞水平。更多还原

【Abstract】 Objective:To detect the CD4+/CD8+ T lymphocyte ratio and the CD4+CD25+ Treg level in peripheral blood of patients with sporadic vitiligo,and to investigate the effect on immune system by the three treatments.Methods:76 patients with sporadic vitiligo were randomly divided into three groups: patients in group 1 were treated by pimecrolimus,patients in group 2 were treated by pimecrolimus and Chinese proprietary,patients in group 3 were treated by pimecrolimus and TGP.The CD4+/CD8+ T lymphocyte ratio and the CD4+CD25+ Treg level in patients of the three groups,before and after treatment,were detected by flow cytometry.Results:In each group,the CD4+/CD8+ T lymphocyte ratio and the CD4+CD25+ Treg level increased after treatment(P<0.05).The CD4+/CD8+ T lymphocyte ratio and the CD4+CD25+ Treg level in group 3 was higher than that in the group 1 which treated by pimecrolimus,but lower than in group 2(P<0.05).The difference showed statistical significance.Conclusion:All three treatments could improve the level of CD4+/CD8+ T lymphocyte ratio and the CD4+CD25+ Treg level in patients with sporadic vitiligo.更多还原