【摘要】 目的比较重组人脑利钠肽(rhBNP)和米力农治疗顽固性充血性心力衰竭(CHF)的治疗效果和安全性。方法入选的84例CHF患者,随机分为试验组42例,对照组42例,在常规纠正CHF的基础上,对照组加用米力农,起始剂量为50μg/min,连用7天;试验组加用rhBNP,首次负荷剂量2.0μg/kg,静注,继而以速率0.01μg/(kg.min),连续静滴,3天,观察并比较两组治疗前后血浆B型脑钠肽(BNP)水平以及左室射血分数(LVEF)等情况。结果 BNP水平的下降程度以及LVEF恢复比较,试验组显著优于对照组(P<0.01)。结论 rhBNP能明显改善CHF患者的血流动力学,在全身临床状况缓解方面优于米力农,疗效显著,安全性较高。更多还原

【Abstract】 Objective Look in the effect of lyophilized recombinant human brain natriuretic peptide(rhBNP) for treatment of refractory heart failure(CHF).Method Eighty-four inpatients with CHF were randomized into an experimental group(n=42) and a control group(n=42).Patients in the control group were given routine anti-HF treatment plus milrinone with an initial dosage of 50μg/min for seven days while patients in the experimental group received routine anti-HF treatment plus Lrh-BNP with an initial loading dose of 2.0μg/kg and then a maintenance dose of 0.01μg/(kg·min) for three days.The level of BNP and left ventricular ventricular ejection fraction(LVEF) of the both groups were observed and recorded after treatment,respectively.Result Thedecreased level of BNP in the experimental group were significantly better than those of the control group(P<0.05).Improvement LVEF were significantly higher than those of the control group(P<0.05).Conclusion LrhBNP could significantly improve CHF sufferers’ hemodynamics.Improvement rate of clinical symptom is better than nitroglycerin.So it could be significant effect and high safety effective for treatment of refractory heart failure.更多还原