【摘要】 目的:观察乌司他丁对急性百草枯(PQ)中毒致肺损伤临床疗效。方法:将41例急性PQ中毒患者随机分为治疗组21例和对照组20例,所有患者均予洗胃、血液灌流+血液透析(HP+HD)及甲基强的松龙静脉注射等综合治疗,治疗组在对照组基础上加用乌司他丁20万单位+0.9%生理盐水100 m1静脉滴注,每日2次,连续3-5 d。比较两组动脉血气、X线胸片(第1、3、5天)变化、多脏器功能障碍综合征(MODS)(≥3个脏器)发生率、病死率、死亡病例的存活时间。结果:治疗后两组的动脉血气及X线胸片等较治疗前均有显著改善(P<0.01),且治疗组明显优于对照组(P<0.05);两组MODS发生率、病死率与死亡病例存活时间无明显差异(P>0.05)。结论:乌司他丁可改善PQ中毒后肺损伤患者动脉血气及X线胸片,对急性PQ中毒肺损伤有积极治疗作用。更多还原

【Abstract】 Objective:To observe the curative effects of Ulinastatin on acute lung injury after paraquat(PQ)poisoning.Methods;41 patients with acute PQ poisoning were randomly divided into treatment group(n=21) and control group(n=20).The control group was accepted sequential blood purification(hemoperfusion and hemodialysis)combined with comprehensive such as gastric lavage,intravenously infused methylprednisolone,and the treatment group was treated by Ulinastatin 2×10~6 units for 3-5 consecutive days based on the control group.The artery blood gas,X-ray film changes,the occurrence rate of multiple organ dysfunction syndrome(MODS),mortality and survival time of the death cases were compared between the two groups.Results;Compared with before treatment,the artery blood gas and X-ray film changes were significantly better in the two groups(P<0.01),especially in the treatment group compared with the control group(P<0.05).The occurrence rate of MODS,mortality and survival time of the death cases were not significantly different between the two groups(P>0.05).Conclusion;Ulinastatin can significantly improve the artery blood gas and X-ray,which has a positive therapeutic effect on pulmonary damage in acute PQ poisoning.更多还原