【摘要】 目的:探讨高血压舒张性心力衰竭患者血清NT-proBNP、hs-CRP、TGF-β1水平与舒张功能的关系。方法:测定高血压舒张性心力衰竭患者(心衰组,n=82)及25例无器质性心脏病者(对照组,n=25)的血清NT-proBNP、hs-CRP和TGF-β1水平,同时采用彩色多普勒超声诊断仪测定左室射血分数(LVEF)、E/A及E/E’。结果:高血压舒张性心力衰竭患者的血清NT-proBNP和hs-CRP水平明显高于对照组(P<0.05),且与舒张功能呈负相关;高血压舒张性心力衰竭患者的血清TGF-β1水平明显低于健康人(P<0.05),且与舒张功能呈正相关。结论:在高血压舒张性心力衰竭患者中,hs-CRP、TGF-β1与心脏舒张功能状态密切相关,可能成为早期诊断舒张性心力衰竭及评估病情的重要指标。更多还原

【Abstract】 Objective:To explore the relationship between diastolic function and serum NT-proBNP,hs-CRP and TGF-β1.Method:Serum NT-proBNP、hs-CRP、TGF-β1 of patients with hypertensive diastolic heart failure(heart failure group,n=82) and people without any cardiovascular disease(control group,n=25) were tested and LVEF,E/ A,E/E’were detected by color Doppler ultrasonic instrument.Results:Compared with healthy people,serum NT-proBNP and hs-CRP were higher in heart failure group and negatively associated with diastolic function.Serum TGF-β1 were lower in heart failure group than that in control group and positively associated with diastolic function. Conclusion:In patients with hypertensive diastolic heart failure,serum NT-proBNP、hs-CRP、TGF-β1 were closely in relation with diastolic function and may be benefit for diagnosis of diastolic heart failure and assessment of diastolic function.更多还原