【摘要】 目的探讨MMP-13在甲状腺癌组织中的表达及其与疾病分期的关系。方法采用免疫组化法检测62例甲状腺癌患者的癌组织以及癌旁正常组织中MMP-13蛋白的表达水平,分析MMP-13表达与甲状腺癌临床分期的关系。结果甲状腺癌组织中MMP-13蛋白表达的阳性率为77.4%(48/62),显著高于癌旁正常组织的8.1%(5/62)(P<0.05);晚期(Ⅲ～Ⅳ期)甲状腺癌患者癌组织中MMP-13蛋白表达的阳性率为94.7%(18/19),显著高于早期(Ⅰ～Ⅱ期)甲状腺癌患者的77.4%(48/62)(P<0.05)。结论甲状腺癌组织中MMP-13蛋白的表达水平升高,MMP-13的高表达与甲状腺癌的疾病进展密切相关。更多还原

【Abstract】 Objective To investigate the expression of MMP-13 in thyroid carcinoma tissues and the relationship between MMP-13 expression and the clinical stages. Methods The expressions of MMP-13 protein were detected by immunohistochemical staining in thyroid carcinoma tissues and para-carcinoma tissues of 62 cases. The relationship between MMP-13 expression and thyroid carcinoma stage was analyzed. Results The positive expression rate of MMP-13 protein in thyroid cancer tissue was 77.4% (48/62), significantly higher than the rate of para-carcinoma tissues which was 8.1% (5/62) (P<0.05). The MMP-13 protein expression rate in late stages (Ⅲ~Ⅳ) of thyroid carcinoma was 94.7% (18/19), significantly higher than the rate of early stages (Ⅰ~Ⅱ) which was 77.4% (48/62) (P<0.05). Conclusions The expression of MMP-13 protein significantly increased in thyroid carcinoma and it is closely related to the progression of thyroid carcinoma.更多还原