【摘要】 目的 探讨血清超敏C反应蛋白(hs-CRP)和糖类抗原CA19-9联合检测在良恶性胆囊疾病鉴别诊断中的临床意义。方法 选择80例胆囊癌患者、100例胆囊良性疾病患者及126例健康正常入,分别应用免疫比浊法和电化学发光法测定血清hs-CRP和CA19-9含量。结果 单独检测胆囊癌患者血清hs-CRP含量的敏感性为82.5%,特异性为68%,单独检测血清CA19-9含量的敏感性为70%,特异性为87%;以hs-CRP和CA19-9任意一项作为阳性指标,敏感性上升为96.25%,而二者均阳性对胆囊癌诊断的特异性上升为91%。结论 血清CA19-9检测是胆囊癌诊断较理想的指标,血清hs-CRP和CA19-9联合检测对胆囊癌诊断有互补作用,对良恶性胆囊疾病的鉴别诊断有重要价值。更多还原

【Abstract】 Objective To investigate the clinical significance of combined detection of serum hypersensitive C-reactive protein(hs-CRP) and carbohydrate antigen CA19-9 in the differential diagnosis of benign and malignant gallbladder disease.Methods 80 gallbladder cancer patients,100 patients with benign disease and 126 healthy controls were chosen.The serum levels of hs-CRP in all studies were detected with immune turbidimetry and the serum levels of CA19-9 in all studies were detected by electrochemical luminescence.Results The sensitivity of separate detection of serum hs-CRP in gallbladder cancer patients was 82.5%,and the specificity was 68%.The sensitivity of separate detection of serum CA19-9 in gallbladder cancer patients was 70%,and the specificity was 87%.However when either hs-CRP or CA19-9 was used as a positive indicator of any one,the sensitivity increased to 96.25%and when both of them being positive was used as an indicator,the specificity increased to 91%.Conclusions Serum CA19-9 level is a better indicator of diagnosis of gallbladder cancer.The combined detection of serum hs-CRP and CA19-9 plays a complementary role in the diagnosis of gallbladder cancer and plays an important role in differential diagnosis of benign and malignant gallbladder disease.更多还原