[Objective]To observe the expression of dickkopf-1(DKK-1) in serum of fluoride bone injury(FBI) patients and analyze the relationship between fluoride bone injury occurrence and DKK-1 expression levels.[Methods]General information of fluoride exposed population was collected by a self-designed questionnaire.Venous blood and random midstream urine were sampled from the subjects to detect their serum and urinary fluoride concentrations and serum DKK-1 protein levels followed by informed consent.Dental fluoros...
【基金】
国家自然科学基金资助项目(编号:81072255)
【更新日期】
2013-10-08
【分类号】
R599
【正文快照】
氟性骨损伤(fluoride bone injury,FBI),是由于机体长期摄入过量氟而引起的以骨代谢紊乱为主要病理特征的慢性代谢性骨病,主要表现为广泛性骨质增生硬化、肌腱韧带钙化。骨周骨化是发生于骨周软组织的钙化和骨化的骨骼病变,也是氟性骨损伤致病致残致瘫的主要原因[1]。研究发现W
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