【摘要】 目的:探讨5-氨基酮戊酸光动力疗法(ALA-PDT)治疗中重度痤疮的有效性及安全性。方法:将116例中重度痤疮患者随机分为两组:治疗组63例,给予ALA-PDT治疗,每周治疗1次,共3次;对照组53例,采用红光照射,每周治疗1次,共3次,在治疗后第2、4、8周对两组患者进行疗效判断和比较,同时观察治疗中的不良反应。治疗组患者随访1年,观察复发率及不良反应。结果:经ALA-PDT治疗的患者总有效率为79.36%;对照组总有效率为41.51%,治疗组疗效明显优于对照组(P<0.05);治疗组患者经1年随访,未复发或持续明显改善者占49.21%,无效或复发者占40.03%。结论:局部5-氨基酮戊酸光动力疗法治疗中重度痤疮安全有效.复发率较低。更多还原

【Abstract】 Objective:To investigate the efficacy and safety of 5-ALA photodynamic therapy in the treatment of moderate to severe acne.Methods:One hundred and sixteen patients with moderate to severe acne were divided into two groups randomly: 63 patients in the treatment group were subjected to ALA-PDT therapy once per week for 3 weeks,while 53 patients in the control group were irradiated with red light once per week for 3 weeks.All patients were evaluated for efficacy and adverse effect at 2,4 and 8 weeks after the last treatment.The patients in the treatment group were followed up for one year,and the relapse rate was recorded.Results:The total effective rate in the treatment group was 79.36%,while that in the control group was 41.51%,there was a significant difference between the two groups(P<0.05).After following -up for one year,the rate of no relapse and continued-improvement in the treatment group was 49.21%,and that of no response and relapse was 40.03%. Conclusion:Topical ALA-PDT is an effective and safe treatment for moderate to severe acne with low rate of relapse.更多还原