【摘要】 目的研究国人帕瑞昔布的临床药代动力学特征。方法 12例择期手术患者,ASAⅠ或Ⅱ级,年龄45～56岁,麻醉诱导前30min静脉注射帕瑞昔布40mg。采用高效液相色谱法测定注药后10、20、30、40、50、60min及1.5、2、4、6、8、12、16、20、24h帕瑞昔布及其代谢产物伐地昔布的血药浓度,用3P97软件计算其药代动力学参数。结果帕瑞昔布的血药浓度-时间数据符合二房室模型。帕瑞昔布和伐地昔布的Cmax分别为(31.58±13.41)μg/ml和(0.91±0.21)μg/ml,Tmax分别为(10.00±0.00)min和(24.00±14.30)min,t1/2β分别为(1.06±0.92)h和(10.65±3.20)h。结论国人帕瑞昔布的临床药代动力学符合二房室模型。更多还原

【Abstract】 Objective To study the clinical pharmacokinetics of parecoxib in Chinese patients. Methods Twelve patients with ASA Ⅰ orⅡ undergoing elective surgery were injected parecoxib 40 mg.Blood samples were collected at 10 , 20 , 30 , 40 , 50and 60min , and 1.5 , 2 , 4 , 6 , 8 , 12 , 16 , 20 and 24hafter injection.The plasma concentration of parecoxib and its product valdecoxib were measured with high-performance liquid chromatography.The pharmacokinetic parameters were calculated with 3P97software package.Results The clinical pharmacokinetics of parecoxib is fitted to a two-compartment model.The main pharmacokinetic parameter including Cmax was ( 31.58±13.41 ) and ( 0.91±0.21 ) μ g / ml , Tmax was ( 10.00±0.00 ) min and ( 24.00±14.30 ) min , and t 1 / 2 β was ( 1.06±0.92 ) h and ( 10.65±3.20 ) h , respectively.Conclusion The clinical pharmacokinetics of parecoxib fits to a two-compartment model in Chinese patients.更多还原