【摘要】 目的:观察帕米膦酸二钠与89Sr联合应用对激素非依赖型前列腺癌(PCa)伴骨转移的治疗效果。方法:将我院收治的29例激素非依赖型PCa伴骨转移患者随机分成A、B两组,A组采用帕米膦酸二钠90mg溶于5%葡萄糖500ml,缓慢滴注4周1次,共2次;B组静脉注射89SrCl21.48mBq/kg,1周后与A组治疗方法相同。采用疼痛视觉模拟法(VAS)评定患者主观骨痛,生活质量(QOL)评分来判定疗效。结果:在疼痛评分方面B组治疗后评分显著低于A组,生活质量评分有效率的差异无统计学意义。结论:帕米膦酸二钠联合89 Sr治疗激素非依赖型PCa伴骨转移在疼痛缓解有效率上高于单独使用帕米膦酸二钠,同时表明帕米膦酸二钠与89Sr具有协同作用,其在不良反应方面无明显增加。更多还原

【Abstract】 Objective:To study the curative effects of pamidronate disodium combined with 89Sr for androgenindependent carcinoma of prostate with bone metastasis.Method:Totally 29patients of androgen-independent carcinoma of prostate with bone metastasis were randomly divided into group A and group B.The patients in group A were received a slow intravenous drip of 90mg pamidronate disodium in 5%glucose solution once per four weeks, totally twice.The patients in group B were received a intravenous injection of 89Srcl2,1.48mBq/kg.Then the patients were treated with the same procedure as group A a week later.Visual analogue scale(VAS)and quality of life(QOL)were analyzed and compared.Result:In terms of VAS,the score of group B was lower than group A and the difference is significant.However,there was no significantly difference between the two groups in QOL. Conclusion:The pain-relief effect of pamidronate disodium combined with 89Sr for androgen-independent carcinoma of prostate with bone metastasis is better than the method of pamidronate disodium alone.Pamidronate disodium and 89Sr had a synergetic effect in pain relief.Side effects were not shown significantly increased when combined therapy was taken.更多还原