【摘要】 目的 探讨肿瘤坏死因子α-308(TNFα-308)基因多态性与肝癌风险的相关性。方法 计算机检索PubMed、Web of Science、中国知网(CNKI)、万方数据库、维普数据库,检索时间为建库~2013年7月,收集关于肿瘤坏死因子α-308基因多态性与肝癌易感性的病例对照研究。应用RevMan 5.1和Stata 12.0软件进行Meta分析。运用Begg秩相关和Egger回归法检测文献发表偏倚。结果 最终纳入19个病例-对照研究,其中包括18篇英文文献和1篇中文文献,共有3002例肝癌患者和3561例对照者。合并统计结果显示,TNFα-308基因多态性可增加肝癌患病风险[AA+GAvsGG,OR=1.73,CI:1.30~2.32,P<0.05]。亚组分析中,东方人群患病率高于西方人群(P<0.05)。经begg漏斗图和egger检验,文献稳定性较好,不存在发表偏倚。结论 TNFα-308基因多态性与肝癌易感性存在显著相关,且东方人群患病率较高。更多还原

【Abstract】 Objective To investigate the association between TNFa-308 polymorphisms and hepatocellular carcinoma risk.Methods All eligible case-control studies published up to July 2013 were identified by searching PubMed.Web of Science,CNKI,Wanfang and VIP.Effect sizes of odds ratio(OR)and 95%confidence interval(95%CI) were calculated using RevMan 5.1 and Statal2.0.Publication bias were tested by using Begg rank correlation and Egger regression.Results A total of 19 case-control studies were recruited,including 18 English and 1 Chinese literatures(3002 cases and 3561 controls).This meta-analysis showed significant association between TNFa-308 polymorphism and HCC[AA +GAvsGG,OR = 1.73,CI:1.30-2.32;P < 0.05].The morbidity rate in Asians is higher than that in the western people(P < 0.05).There were no publication bias in the studies by Begg’ and Egger’ test.Conclusion This meta-analysis indicated that TNFa-308(G/A) polymorphism was associated with the risk of hepatocellular carcinoma.And the risk of HCC in Asians is higher than that in the western people.更多还原