【摘要】 目的分析冠心病(CAD)患者血清脂蛋白相关磷脂酶A2(Lp-PLA2)、氧化低密度脂蛋白(ox-LDL)水平。方法分别检测100例急性冠脉综合征(ACS)、75例稳定性心绞痛(SAP)患者和50例健康人对照者的血清Lp-PLA2、ox-LDL水平及CAD病变程度,分析其相关关系。结果与健康人对照组相比,CAD患者血清Lp-PLA2、ox-LDL水平均显著升高(P<0.01);与SAP组相比,ACS组血清Lp-PLA2、ox-LDL、肌钙蛋白I(TnI)水平及Gensini积分均显著升高(P<0.01)。相关性分析显示,CAD患者Gensini积分分别与血清Lp-PLA2(r=0.426,P<0.01)、ox-LDL(r=0.331,P<0.01)水平呈正相关,Lp-PLA2与ox-LDL之间亦显著正相关(r=0.238,P<0.01)。多元回归分析显示,CAD患者血清Lp-PLA2(β=0.366,P<0.01)和ox-LDL(β=0.253,P<0.01)水平共同决定了22.7%的Gensini积分变化;Gensini积分是血清Lp-PLA2的唯一显著的独立预测因子(β=0.420,P<0.01);LDL胆固醇(LDL-C)(β=0.411,P<0.01)、Gensini积分(β=0.285,P<0.01)共同决定了25.9%的ox-LDL变化。结论 CAD患者血清Lp-PLA2、ox-LDL水平升高,且与动脉粥样硬化(As)病变程度密切相关。更多还原

【Abstract】 Objective To investigate the levels of serum lipoprotein associated phospholipase A2(Lp-PLA2) and oxidized low-density lipoprotein(ox-LDL) in patients with coronary artery disease(CAD).Methods The level of serum Lp-PLA2 and ox-LDL were measured in 100 patients with acute coronary syndromes(ACS),75 with stable angina pectoris(SAP) and 50 healthy controls,and the Gensini score of each CAD patient was obtained.Results Compared to controls,both the levels of Lp-PLA2 and ox-LDL in patients with CAD were significantly increased(P<0.01).Furthermore,the levels of Lp-PLA2,ox-LDL,TnI and the Gensini score in patients with ACS were higher than those in patients with SAP(P<0.01).Lp-PLA2(r=0.426,P<0.01) and ox-LDL(r=0.331,P<0.01) levels were positively related with Gensini score,and Lp-PLA2 levels were also correlated with ox-LDL(r=0.238,P<0.01).The multiple linear regression analysis showed that Lp-PLA2(β=0.366,P<0.01) and ox-LDL(β=0.253,P<0.01) jointly determined 22.7% of the variation of Gensini score in patients with CAD,and LDL-C(β=0.411,P<0.01) and Gensini score(β=0.285,P<0.01) jointly determined 25.9% of the variation of ox-LDL levels.Gensini score was the only significant independent predictor of Lp-PLA2 levels(β=0.420,P<0.01) in the patients with CAD.Conclusion Both the levels of serum Lp-PLA2 and ox-LDL were increased and associated with the severity degree in patients with CAD.更多还原