【摘要】 目的:比较齐拉西酮与奎硫平对精神分裂症患者体质量、糖脂代谢的影响。方法:将82例精神分裂症患者随机分为齐拉西酮组与奎硫平组,每组各41例,分别给予齐拉西酮和奎硫平治疗6个月。于治疗前和治疗6个月后分别测体质量、空腹血糖及血脂总胆固醇(CHO)、三酰甘油(TG)、低密度脂蛋白(LDL)及高密度脂蛋白(HDL)进行比较。结果:齐拉西酮组治疗前后各项指标差异无统计学意义(P>0.05),而奎硫平组治疗6个月后体质量、空腹血糖、CHO及TG显著升高(P<0.05或P<0.01)。结论:奎硫平可能对精神分裂症患者体质量、血糖及血脂有较多影响,而齐拉西酮影响较小。更多还原

【Abstract】 Objective:To investigate the effects of ziprasidone and quetiapine on body weight and glucose and lipid metabolism in schizophrenic patients. Method:82 patients with schizophrenia were randomly divided into two groups each of which ( n = 41) were treated with either ziprasidone or quetiapine. Body weight,fasting blood-glucose and blood lipid including total cholesterol ( CHO) ,triglycerides ( TG) ,low density lipoprotein ( LDL) and high density lipoprotein ( HDL) were measured before and 6 months after the treatment. Results:The ziprasidone group showed no significant difference on body weight,fasting blood-glucose and blood lipid before and after 6 months treatment ( P > 0. 05) ,while the quetiapine group showed significant increases on body weight,fasting blood-glucose,CHO and TG ( P < 0. 05 or P < 0. 01) . Conclusion:Ziprasidone may not affect body weight,blood glucose and blood lipid,while quetiapine may have more effect on body weight,blood glucose and blood lipid.更多还原