【摘要】 目的探讨同步放化疗与序贯放化疗治疗Ⅲ期非小细胞肺癌的临床疗效及安全性。方法对我院住院治疗的86例Ⅲ期非小细胞肺癌患者临床资料进行分析。86例患者中行同步放化疗者46例,行序贯放化疗者40例。比较两组近期疗效、中位生存时间及毒副反应。结果同步放化疗组与序贯放化疗组患者治疗有效率(CR+PR)分别为69.6%和50.0%,差别具有统计学意义(P<0.05);同步放化疗组中位生存时间显著优于序贯放化疗组(P<0.05);骨髓抑制、放射性食管炎、消化道反应及放射性肺炎是两组的主要毒副反应,同步放化疗组患者Ⅲ～Ⅳ级不良反应发生率高于序贯放化疗组,但两者差异无统计学意义(P>0.05)。结论与序贯放化疗相比,同步放化疗可显著提高Ⅲ期非小细胞肺癌近期疗效,延长生存期。更多还原

【Abstract】 Objective To explore the effect and security of concurrent and sequential chemo-radiotherapy in the treatment of patients with non-small cell lung cancer at stage Ⅲ.Methods.The clinical data of 86 patients with non-small cell lung cancer at stage Ⅲ from February 2006 to February 2009 were retrospectively analyzed,which included 46 cases undergoing concurrent chemo-radiotherapy and 40 cases receiving sequential chemo-radiotherapy treatment.Short term curative effect,median survival time and side effects were compared between two groups.Results The effective rates of treatment were 69.6% and 50.0% respectively in the concurrent chemo-radiotherapy group and in the sequential chemo-radiotherapy group with significant difference(P<0.05).The median survival time in the concurrent chemo-radiotherapy group was superior to the sequential chemo-radiotherapy group(17.9 months vs 12.3 months,P<0.05).The main adverse reactions were myelosuppression,radiation esophagitis,radiation pneumonitis and gastrointestinal reaction in the two groups.The incidence of Ⅲ~Ⅳ grade side effects in the concurrent chemo-radiotherapy group were higher than that in the sequential chemo-radiotherapy group with no significant difference(P>0.05).Conclusion While compared with sequential chemo-radiotherapy,concurrent chemo-radiotherapy can greatly improve short term curative effects and survival time for patients with non-small cell lung cancer at stage Ⅲ.更多还原