【摘要】 目的探讨婴儿母乳喂养与儿童时期发生支气管哮喘有无关联性。方法检索儿童发生支气管哮喘与婴儿时期是否母乳喂养的病例对照研究文献,进行meta分析。结果符合纳入标准的文献共有10篇,国外研究4篇,国内研究6篇。分析发现,母乳喂养婴儿在儿童时期发生哮喘的风险相对于非母乳喂养婴儿显著降低(OR=0.78,95%CI=0.65~0.93)。进一步行亚组分析,发现支气管哮喘风险降低主要出现在中国儿童研究中(OR=0.64,95%CI=0.48~0.85),而在非中国儿童研究中,母乳喂养并不能降低支气管哮喘发病风险(OR=1.00,95%CI=0.94~1.07)。结论婴儿期母乳喂养,可以有效降低中国儿童发生哮喘的风险。更多还原

【Abstract】 Objective To investigate the correlation between breastfeeding and childhood asthma.Methods Systematic search and meta-analysis were conducted to literatures of childhood asthma and breastfeeding.Results A total of 10 publications that reported the associations between breastfeeding and childhood asthma were collected,including 6 studies for the Chinese,and 4 studies for non-Chinese.The analysis revealed the risk of childhood asthma was lower in children with breastfeeding than that of non-breastfeeding(OR=0.78,95%CI=0.65-0.93).From subgroup analysis,it was found that the reduced risk of childhood asthma mostly happened in Chinese children instead of non-Chinese ones(OR=0.64,95%CI=0.48-0.85).Conclusion Breastfeeding can effectively reduce the risk of childhood asthma in Chinese children.更多还原