The human lung epithelial cell line A549 was exposed to Nano-SiO2and quartz of two kinds of particle size(KWC-Q3 and KWC-Q4) for 24 hours.The effects of them to cell viability,leakage of lactate dehydrogenase(LDH),secretion of interleukin 6(IL-6) and tumor necrosis factor(TNF-α) were studied.This study demonstrated that: comparing with KWC-Q3 and KWC-Q4,Nano-SiO2 in A549 cells performed the highest cytotoxicity.The viability of A549 cells was significantly decreased in a dose-dependent manner after exposure...
【基金】
国家自然科学基金项目(批准号:41130746)
【更新日期】
2013-07-30
【分类号】
R114
【正文快照】
石英是地球表面分布最广的矿物之一,且应用范围广,很多职业环境中都有石英粉尘存在[1]。早在1987年,国际癌症研究机构(InternationalAgency for Research on Cancer)已将石英列为致癌物质,大量流行病学调查和动物试验也都证明吸入石英粉尘能够导致肺部纤维化甚至形成矽肺[2-3]?
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