【摘要】 目的制备聚乙烯醇/魔芋胶复合凝胶,考察处方工艺因素对其体外释药的影响。方法以盐酸小檗碱为模型药物,采用冷冻-解冻法制备聚乙烯醇/魔芋胶复合凝胶。通过体外药物释放研究,考察凝胶材料用量、聚乙烯醇/魔芋胶比例、药物量、反复冷冻-解冻次数等因素对复合凝胶释药特性的影响。结果随着凝胶材料用量、载药量和冷冻-解冻次数增加,复合凝胶的释药速度减慢;聚乙烯醇/魔芋胶比例为2∶1时,药物释放最慢。结论聚乙烯醇/魔芋胶复合凝胶对盐酸小檗碱具有缓释效果,可通过处方工艺因素调节其释药特性。更多还原

【Abstract】 Objective To prepare polyvinyl alcohol(PVA)/konjac glucomannan(KGM)complex hydrogel,and investigate the influence of formulation and preparation factors on drug released.Methods The PVA/KGM complex hydrogel containing berberine hydrochloride as a model drug were prepared by freezing and thawing method of physical crosslinking of the PVA and KGM solution.The effects of the amount of matrix materials and drug,PVA/KGM ratio,and freezing and thawing cycle times on drug release characteristics were investigated.Results Berberine hydrochloride could be released slowly from the PVA/KGM complex hydrogel.With an increased in the amount of matrix materials and drug,freezing and thawing cycle times,the drug release rate was decreased.When the ratio of PVA/KGM was 2∶1,the drug release rate was the slowest.Conclusion The PVA/ KGM complex hydrogel can used as a sustained-release preparation for berberine hydrochloride,drug release characteristics can be controlled by adjusting the formulation and preparation.更多还原