【摘要】 目的探讨阿托伐汀治疗对非酒精性脂肪肝(NAFLD)患者动脉弹性的影响。方法将135例患者随机分为治疗组(降脂+生活干预,69例)和对照组(生活干预,66例),降脂药采用阿托伐他汀20 mg,每晚一片,半年后观察结束。结果半年后,两组在降低体重、血脂、减轻脂肪肝及肝功能损伤较治疗前有明显疗效(P<0.05);在降低动脉弹性方面,治疗组治疗前后差异有显著性意义(P<0.05),而对照组治疗前后差异无显著性意义,且治疗组疗效明显优于对照组(P<0.01)。结论阿托伐他汀降脂治疗可以有效降脂、减轻体重、降低血糖,改善NAFLD患者脂肪肝程度,逆转动脉硬化。更多还原

【Abstract】 Aim To evaluate the effect of statin treatment on the arteral elastcity in patients with non-alcoholic fatty live disease( NAFLD).Methods 135 cases with NAFLD were randomly divided into treatment group( atorvastatin 20 mg + life intervene,n = 69) and control group( life intervene,n = 66),the period of the treatment is a half of one year.Results There were significant decrease in weight,cholesterol-level,the transaminase of live,the degree of fatty liver in two groups; and there were significant decrease on brachial-ankle pulse wave velocity( Ba-PWV) in treatment group,no change happened in control group.So the effect of treatment group was superior to control group.Conclusion There is a significant effect of atorvastatin treatment on lipid-lowering,weight loss,improving the degree of fatty liver,reversing the arteral elastcity in patients with NAFLD.更多还原