【摘要】 生物大分子药物洗脱支架是指载有核酸、抗体、酶、细胞因子等活性生物大分子的冠状动脉支架。生物大分子可针对再狭窄的分子机制,作用于指定环节的特定靶点,具有高度特异性,因此生物大分子药物洗脱支架可望成为解决支架内再狭窄和晚期血栓的根本途径。文章就目前生物大分子药物洗脱支架国内外最新研究进展作一综述。更多还原

【Abstract】 As with drug-eluting stents(DES),biomacromolecule-eluting stents can deliver biologically active agents such as nucleic acid,antibody,enzyme and cell factor.Biological active agents can selectively act at specific target location through molecular mechanism of coronary artery restenosis.This seems to be a promising treatment strategy for preventing in-stent restenosis(ISR) while simultaneously reducing the risk of stent thrombosis.This article reviews recent developments in biomacromolecule-eluting stents.更多还原