【摘要】 目的探讨脑小血管病(SVD)所致轻度认知功能障碍(VMCI)患者的血浆同型半胱氨酸(Hcy)水平与认知功能的关系。方法测定SVD所致MCI患者84例及60例健康体检者的血浆Hcy水平及叶酸、维生素B12水平,入选者均完善神经心理筛查项目,观察两组患者Hcy水平及与蒙特利尔认知评估量表(MoCA)评分总分及各亚项分的相关性。结果 VMCI患者血浆Hcy水平显著高于健康对照组(P<0.01),叶酸、维生素B12水平、MoCA总分及立方体构图、画钟试验、目标数字识别、延迟回忆亚项评分低于对照组(P<0.01);VMCI组中Hcy水平与叶酸、维生素B12水平及MoCA总分呈负相关(P<0.05)。结论血浆Hcy水平升高与SVD患者的认知损害密切相关,VMCI患者在抽象空间构图和注意力等方面较早出现减退。更多还原

【Abstract】 Objective To explore the relationship between plasma homocysteine(Hcy)and vascular mild cognitive impairment(VMCI)in patients with cerebral small vessel disease(SVD).Methods Plasma Hcy,folic acid and VitB12were determined in 82cases of VMCI patients with cerebral SVD(VMCI group)and 60healthy subjects(control group),who were scored with Montreal Cognitive Assessment(MoCA).Correlation between plasma Hcy level and MoCA scores was analyzed.Results Plasma Hcy level in VMCI group was significantly higher than that in control group(P<0.01),but plasma levels of folic acid and VitB12,MoCA total score and MoCA subscore with regard to composition of the cube,clock drawing test,recognition of target digit and delayed recall were lower than control group(P<0.01).Plasma Hcy level was negatively correlated with plasma level of folic acid and VitB12and MoCA total score in VMCI group(P<0.05).Conclusion Increased plasma level of Hcy could be closely related to cognitive impairment in patients with cerebral SVD,and cognitive of abstract space configuration and attention might be decreased earlier in patients with VMCI.更多还原