【摘要】 目的探讨2型糖尿病人群一级亲属(FDR)的胰岛素抵抗指数的变化和临床意义。方法分别测定广州地区2型糖尿病家庭和健康人群家庭成员的体质量指数(BMI)、腰围、臀围、空腹胰岛素(FIN)、空腹血糖(FBG)、血脂的水平,计算胰岛素抵抗指数(IRI)。结果 (1)2型糖尿病与其一级亲属比较,FBG、体脂分布百分比(BF%)差异有统计学意义(P<0.05)。(2)2型糖尿病与健康对照组比较,BF、IR、FBG、三酰甘油(TG)、高密度脂蛋白(HDL)差异有统计学意义(P<0.05)。(3)2型糖尿病其一级亲属与健康对照组比较,BMI、IR、FBG、TG、HDL差异有统计学意义(P<0.05)。(4)IR与BMI、BF、HBCI、TG、HDL有明显相关关系。结论推测2型糖尿病的一级亲属存在胰岛素抵抗高危易感性。肥胖和胰岛素抵抗在向2型糖尿病的发生和发展过程中起了一定作用。更多还原

【Abstract】 Objective To investigate the change of insulin resistance index(HOMA-IR) and its clinical significance in the first-degree relatives of type 2 diabetes mellitus(T2DM) crowd.Methods To measure the body weight index(BMI),waist,hip,fasting insulin(FIN),fasting blood glucose(FBG) and the blood lipids levels of T2DM families and the healthy controls in Guangzhou area,and to calculate HOMA-IR.Results(1)There were statistical differences of FBG and body fat(BF) between the T2DM patients and their first-degree relative members(P<0.05).(2)There were statistical differences in BF,IR,FBG,TG,and HDL between the T2DM group and the healthy control group(P<0.05).(3)There were statistical differences in BMI,IR,FBG,TG and HDL between the first-degree relatives of T2DM and the healthy control group.(4) It had significant correlativity between IR with BMI,BF,HBCI,TG and HDL.Conclusion It is conjectured that there is a high-risk susceptibility of IR in the first-degree relatives of T2DM,obese and IR play a certain role in the occurrence and the developing process of T2DM.更多还原