【摘要】 目的探讨和评价应用介入微导管窦内溶栓治疗产后重型脑静脉窦血栓的疗效。方法2008年5月至2011年6月收治11例产后重型脑静脉窦血栓形成患者,采用微导管置入静脉窦血栓内,使用尿激酶溶栓。术后2周采用磁共振静脉造影(MRV)评价溶栓后静脉窦通畅情况。结果出院前11例患者腰椎穿刺时脑脊液压在200 mmH2O以下,MRV检查证实9例静脉窦主干完全通畅,皮层静脉和深静脉恢复正常;2例部分通畅,皮层静脉和深静脉部分代偿。9例患者的症状、体征完全改善,2例留有肢体功能障碍。结论应用血管内静脉微导管溶栓治疗重型脑静脉窦血栓形成是一种安全、有效的治疗手段。更多还原

【Abstract】 Objective To evaluate the therapeutic efficacy of percutaneous intra-sinus thrombolysis by using urokinase perfusion via a microcatheter in treating severe intracranial dural sinus thrombosis that occurs during puerperous period.Methods During the period from May 2008 to June 2011 a total of 11 patients with severe cerebral venous sinus thrombosis that occurred during puerperous period were admitted to authors’ hospital.Percutaneous intra-sinus thrombolysis by using urokinase perfusion via a microcatheter that was placed in the venous sinus thrombus was carried out in all patients.Magnetic resonance venography(MRV) was performed two weeks after the treatment to assess the re-canalization of the venous sinus.The results were analyzed.Results At the time of discharge,the intracranial pressure was below 200 mmH2O in 11 patients.MRV confirmed that in 9 patients the main stem of venous sinus was patent,and the cortex veins as well as the deep veins returned to normal.In 2 patients it was noted that the cortex veins and the deep veins were partially compensated.In 9 patients the clinical symptoms and signs were improved.Mild residual dysfunction of the limbs was seen in 2 patients.Conclusion For severe intracranial dural sinus thrombosis that occurs during puerperous period,percutaneous intra-sinus thrombolysis by using urokinase perfusion via a microcatheter is an effective and safe treatment.更多还原