【摘要】 目的:评价平阳霉素联合曲安奈德治疗疤痕疙瘩的临床疗效和安全性。方法:将135例疤痕疙瘩患者随机分为A组、B组和C组,每组45例,A组患者采用局部注射平阳霉素及曲安奈德,1次/月,连续1~2次;B组患者局部注射曲安奈德,1次/月,连续1~2次;C组患者局部注射平阳霉素,1次/月,连续1~2次。结果:A组患者治疗后基愈率为62.22%、总有效率为88.89%;B组患者治疗后基愈率为48.89%、总有效率为68.89%;C组患者治疗后基愈率为31.11%、总有效率为64.44%。A组与B组、C组疗效比较,差异均有统计学意义(χ2=5.4040,P=0.0201;χ2=7.5155,P=0.0061);B组与C组疗效比较,差异无统计学意义(χ2=0.2000,P=0.6547)。三组患者均无明显不良反应。结论:平阳霉素联合曲安奈德治疗疤痕疙瘩安全、有效。更多还原

【Abstract】 Objective To investigate the clinical effect and safety of pingyangmycin combined with triamcinolone acetonide in the treatment of keloids.Methods One hundred and thirty-fve outpatients with keloids were divided into group A,B and C randomly.Forty-fve patients in group A were treated with local pingyangmycin and triamcinolone acetonide injection once a month for 1 to 2 times.Forty-fve patients in group B were treated with triamcinolone acetonide once a month for 1 to 2 times.Forty-five patients in group C were treated with pingyangmycin once a month for 1 to 2 times.Results The results of group A after treatment showed that the cured rate and total effect rate were 62.22% and88.89%,respectively.The results of group B after treatment showed that the cured rate and total effect rates were 48.89% and 68.89% respectively.The results of group C after treatment showed that the cured rate and total effect rate were 31.11% and 64.44% respectively.The effect rate in group A was significant higher than that of group B and C(χ2= 5.4040,P=0.0201;χ2= 7.5155,P=0.0061).The effect rate in group B was no statistical signifcant with group C(χ2=0.2000,P=0.6547).Conclusion This investigation indicates that pingyangmycin combined with triamcinolone acetonide are an effcacy and safety therapy in the treatment of keloids.更多还原