【摘要】 作为非病毒基因载体,磁性纳米基因载体主要指无机非金属材料纳米氧化铁和铁氧体等,近年来其研究广受关注。文中对非病毒基因载体磁性纳米颗粒的种类、性质、制备方法和表面修饰进行综述,并介绍了磁性纳米基因载体介导的体内外基因转染,以及联合磁热疗与靶向治疗癌症领域的相关进展。更多还原

【Abstract】 Magnetic nano-gene mainly refers to inorganic non-metallic materials including nano ferric oxide and ferrite,etc.Recently,research causes wild public concern on magnetic nanoparticles as non-virus gene vector.The paper demonstrates the types and properties,the common preparation methods and surface modification of magnetic nanoparticles as non-virus gene carrier.And the latest application of gene transfection of magnetic nanoparticles in vitro and in vivo,combined with magnetic fluid hyperthermia(MFH) or target therapy to cancer are reviewed.更多还原