刺五加注射液对冠心病血瘀症患者ET1

【摘要】 血浆内皮素(ET)是一种低分子的血管活性肽,具有细胞信使样的生理活性,有收缩血管、促进血管平滑肌增生与细胞粘连的作用。血浆内皮素水平升高可使血管痉挛,血栓形成与动脉粥样硬化,是心脑血管疾病发生发展的原因之一。中药治疗心脑血管疾病有着良好的疗效,其机理可能作用于血浆内皮素等环节。冠脉斑块阻塞或冠脉痉挛引起缺血缺氧会刺激局部心肌组织合成和释放大量血浆内皮素1(ET1),而血浆内皮素1的增多又会加重心肌缺血缺氧及产生细胞毒效应,形成恶性循环。所以,目前降低血浆内皮素1含量及活性已成为冠心病治疗用药选择的关键。更多还原

【Abstract】 the plasma endothelin(ET)is a kind of low molecular peptides,with cellular messenger kind of physiological activity,blood vessels, promote vascular smooth muscle proliferation and cell adhesion.Traditional Chinese medicine in the treatment of cardiovascular and cerebrovascular diseases have a good effect,the mechanism may act on the plasma endothelin.Coronary plaque or coronary spasm caused by ischemia and hypoxia can stimulate local myocardial tissue synthesis and release large amounts of plasma endothelin 1(ET1),and plasma endothelin 1increase will aggravate myocardial ischemia and hypoxia and the generation of cytotoxic effect,forming a vicious spiral.So,the content and activity of plasma endothelin 1has become the key to reduce coronary heart disease treatment.更多还原