Objective: To study the effect of psychological intervention and its different patterns on pain and anxiety associated with amniocentesis. Methods: A total of 413 pregnant women with 16. 5 to 22. 6 weeks of gestation age were randomly divided into two groups: counseling group( group A,n = 205) and group of counseling and light pressure effleurage during the amniocentesis( group B,n = 208). Both groups were given psychological counseling before amniocentesis,and group B was given additional light pressure ef...