【摘要】 目的:探讨口服避孕药治疗对基础卵泡刺激素(FSH)水平升高的不孕妇女子宫内膜容受性的影响。方法:收集基础FSH>10U/L的不孕妇女15例,口服避孕药治疗3个月,比较治疗前后黄体中期子宫内膜的病理变化、胞饮突发育情况和子宫内膜容受性生化标记因子,包括白血病抑制因子(LIF)、血管内皮生长因子(VEGF)、基质金属蛋白酶9(MMP9)、整合素β3的表达水平。结果:治疗前分泌中期子宫内膜占60%(9/15),治疗后全部内膜标本均显示分泌中期内膜,差异有统计学意义(P<0.05)。治疗前完全发育胞饮突率(35.6%)低于治疗后(57.8%)(P<0.05)。治疗前内膜腺体的LIF和整合素β3表达水平分别为1.91±0.46和2.10±0.26,低于治疗后的2.41±0.50和2.39±0.41(P<0.05)。结论:高FSH不孕患者口服避孕药治疗后子宫内膜发育的同步性得到改善,子宫内膜容受性增加。更多还原

【Abstract】 Objective: To explore the changes of endometrial receptivity in infertile women who were treated by oral contraceptive pills due to an elevated basal follicle stimulating hormone (FSH). Methods:Fifteen infertile women with elevated FSH were administrated with oral contraceptive pills for three cycles. The endometrial biopsies were performed in the mid-luteal phase before (group 1) and after (group 2) the therapy. The parameters of endometrial receptivity including the development of pinopodes and biochemical markers, e.g. leukemia inhibitory factor (LIF), vascular endothelial growth factor (VEGF), integrin β3, were compared. Results:All of 15 mid-luteal biopsies (100.0%) were in-phase in group 2. However, only 9 out of 15 (60.0%) of biopsies showed the in-phase endometria in group 1. The synchronization of endometrial development was significantly higher in group 2. The fully developed pinopodes rate was also higher in group 2 (57.8%) than in group 1 (35.6%, P<0.05). The mean LIF and integrin β3 levels were 2.41±0.50 and 2.39±0.41 in group 2, significantly higher than 1.91±0.46 and 2.10±0.26 in group 1 (P<0.05). Conclusion: Oral contraceptive pills administration improved endometrial receptivity and synchronous development in women with elevated basal FSH.更多还原