【摘要】 目的:评价miR-21的高表达与乳腺癌预后的相关性。方法:检索PubMed,MEDLINE,EMBASE,Web of science,维普,CNKI数据库,收集从建库至2013年9月期间关于miR-21的高表达与乳腺癌预后相关性的文献,用meta分析方法评价miR-21的高表达是否与乳腺癌的预后相关。结果:共纳入4篇文献(总计548个病例),总生存率(OS)HR的合并值为1.61(95%CI:1.09至2.37,P<0.05)。结论:miR-21的高表达是乳腺癌预后的一个危险因素。更多还原

【Abstract】 Objective:To evaluate the correlation between the high expression of miR-21 and the prognosis of breast cancer.Methods:Eligible studieswhich studied the correlation between the high expression of miR-21 and the prognosis of breast cancer were collected through searching PubMed,MEDLINE, EMBASE, and Wed of science,VIP,CNKI databases. Ameta analysismethod was used to evaluate whether the high expression of miR-21 has an association with the prognosis of breast cancer. Results:A total of 4 studies(548 cases)were involved in thismeta-analysis. For overall survival(OS), the pooled hazard ratio(HR)of higher miR-21 expression in cancerous tissueswas 1.61(95%CI: 1.09~ 2.37,P< 0.05).Conclusions:High expression ofmiR-21 is a risk factor of breast cancer.更多还原