【摘要】 目的了解山东省社区人群戊型肝炎(hepatitis E,HE)流行状况,为HE防控工作提供依据。方法利用2006年"山东省乙型病毒性肝炎血清流行病学调查"保留的资料及样本,采用酶联免疫吸附试验(enzymelinked immunosorbent assay,ELISA)方法检测戊型肝炎病毒(hepatitis E virus,HEV)IgG抗体(抗-HEV IgG),采用权重调整法估算不同人群抗-HEV IgG流行率。结果共对6 447人的血标本进行检测和分析,山东省1~59岁人群抗-HEV IgG流行率为11.47%(95%CI:8.92~14.02),男女差异无统计学意义(Ⅹ2=0.00,P=0.995),随年龄增长流行率呈逐渐上升趋势;城乡人群差异无统计学意义(Ⅹ2=0.03,P=0.859);东、中、西部地区人群流行率分别为22.77%、7.97%和10.59%,东部高于中部和西部地区,差异有统计学意义(Ⅹ21=81.58,P1<0.001;Ⅹ22=42.61,P2<0.001);沿海高于内陆,差异有统计学意义(Ⅹ2=99.45,P<0.001)。结论山东省为HE流行区,应重视山东省特别是东部沿海地区戊肝控制工作。更多还原

【Abstract】 Objective To know the prevalence status of hepatitis E virus( HEV) in Shandong Province and to provide evidence for the policy-making about hepatitis E prevention and control. Methods The remaining blood samples in the latest provincial hepatitis B serosurvey which was carried out in 2006 were used to test anti-HEV IgG by enzyme-linked immunosorbent assay( ELISA). The weighted prevalence rates of anti-HEV IgG by the age,gender and residential area were analyzed. Results A total of 6 447 subjects were included in the final analysis. The overall prevalence rate of antiHEV IgG was 11. 47%( 95% CI: 8. 92-14. 02) among natural population in Shandong Province. No significant difference was found between males and females( Ⅹ2= 0. 00,P = 0. 995). The prevalence increased with age. No significant difference could be found for the prevalence of anti-HEV IgG between the rural and urban areas( Ⅹ2= 0. 03,P = 0. 859). The prevalence rate was much higher in eastern areas than those in central and western areas of the province( Ⅹ21= 81. 58,P <0. 001; Ⅹ22= 42. 61,P2< 0. 001). Compared with the population who lived in the non-coastal areas,the prevalence was much higher among those who lived in the coastal areas( Ⅹ2= 99. 45,P < 0. 001). Conclusions HEV was prevalent in Shandong province and more measures should be taken for its prevention and control,especially in the eastern and coastal areas.更多还原