【摘要】 目的了解上海市乙肝病毒感染的家庭聚集性状况及其感染模式,为完善乙肝防治策略提供依据。方法 2010年抽取上海市6个区的乙肝病人337例和乙肝表面抗原阳性者292例,对其全部家庭成员进行调查,并采集静脉血5 ml检测乙肝血清学指标。结果 1 567名调查对象乙肝总感染率为77.28%,629户家庭共有15种乙型肝炎病毒(hepatitis B virus,HBV)感染模式,其中以乙肝表面抗体(hepatitis B surface antibody,anti-HBs)和乙肝核心抗体(hepatitis B core antibody,anti-HBc)二项阳性,乙肝表面抗原(hepatitis B surface antigen,HBsAg)、乙肝e抗体(hepatitis Be antibody,HBeAb)、anti-HBc三项阳性和anti-HBs、HBeAb、anti-HBc三项阳性等模式为主,构成比分别为30.64%、26.67%和10.24%。20岁以下年龄组HBV感染率(27.40%)低于其他年龄组(P<0.001);男性家庭成员HBV感染率(78.51%)稍高于女性(76.12%)(P=0.270)。子女的感染率(44.58%)低于父母的感染率(87.77%),差异有统计学意义(P<0.001);丈夫的感染率(89.50%)与妻子的感染率(86.12%)差异无统计学意义(P=0.170)。结论上海市乙肝病毒感染呈家庭聚集性,应对与乙肝病毒感染者共同生活的家庭成员及时接种乙肝疫苗,并做好日常生活中的预防,以阻断因生活接触导致的乙肝病毒感染。更多还原

【Abstract】 Objective To understand family clustering status of hepatitis B virus(HBV) infection and family infection mode in Shanghai.Methods A total of 337 patients with hepatitis B and 292 hepatitis B surface antigen(HBsAg) carriers in six districts of Shanghai were sampled in 2010 and all of their family members were subjected to questionnaires,together with 5 ml of venous blood being collected for detection of HBV serology markers.Results The total HBV infection rate was 77.28% in 1 567 subjects.Fifteen kinds of HBV infection modes were observed in 629 families,in which three modes including hepatitis B surface antibody(anti-HBs) and hepatitis B core antibody(anti-HBc) double positive,HBsAg,hepatitis Be antibody(HBeAb),anti-HBc triple positive,and anti-HBs,HBeAb,anti-HBc triple positive were in top three with the proportion of 30.64%,26.67% and 10.24%,respectively.The HBV infection rate below 20-year-old age group(27.40%) was lower than those of other age groups(P < 0.001).The HBV infection rate of male family members(78.51%) was slightly higher than that of females(76.12%) but without statistical significance(P = 0.270).The infection rate of children(44.58%) was lower than that of parents(87.77%) with statistical significance(P < 0.001).The difference of HBV infection rate between husbands(89.50%) and wives(86.12%) was not statistically significant(P =0.170).Conclusions The HBV infection in Shanghai showed the obvious family-clustering.In order to block the HBV infection within family by close contact,timely hepatitis B vaccination should be administered to family members who live together with HBV carriers,and the prevention of HBV infection should be strengthened in daily family life.更多还原