【摘要】 目的探讨丙型肝炎病毒(hepatitis C virus,HCV)慢性感染者抗F蛋白抗体阳性率的影响因素。方法收集215例抗HCV抗体阳性患者的血清标本,用间接酶联免疫吸附法(enzyme-linked immuno sorbent assay,ELISA)检测血清抗F蛋白抗体,并进行HCV RNA检测和基因分型。结果抗F蛋白抗体阳性率为66.0%(142/215);单因素分析结果显示,年龄20～岁和51～岁间抗F抗体阳性率差异有统计学意义(P<0.001)、是否合并肝硬化的F抗体阳性率差异有统计学意义(P=0.020),而性别、HCV 1b和2型、HCV RNA阳性和阴性抗F抗体阳性率间差异均无统计学意义(均有P>0.05);将年龄和肝硬化纳入Logistic回归模型得出,年龄为51～岁以及合并肝硬化会增加血清抗F蛋白抗体阳性的可能性,OR(95%CI)值分别为3.45(1.56～7.62)和1.35(1.05～1.73)。结论年龄增长、合并肝硬化会增加血清抗F蛋白抗体阳性的可能性,性别、HCV分型及HCV RNA则不会影响。更多还原

【Abstract】 Objective To investigate the distribution and influencing factors of serum anti-F in patients with chronic hepatitis C virus(HCV) infection.Methods Serum samples of 215 HCV chronic infected patients were recruited.Indirect enzyme-linked immuno sorbent assay(ELISA) were employed to detect serum anti-F protein antibody.HCV RNA and genotyping were detected respectively.Results There were significant correlations among anti-F antibody,age and patients with cirrhosis,but not sex,HCV RNA or types of HCV RNA.Logistic regression analysis showed that the positive rate of anti-F was higher in patients over 50 years old(OR=3.45,95% CI:1.56-7.62),and in patients with cirrhosis(OR=1.35,95% CI:1.05-1.73).Conclusions The results indicate that age and cirrhosis play roles in the anti-F antibody in patients with chronic HCV infection.更多还原