【摘要】 目的检测冠心病患者介入治疗前后血管内皮生长因子(VEGF)的动态变化并探讨其与患者诊断、治疗及预后的关系。方法双抗体夹心酶联免疫法(ELISA)检测冠心病患者介入治疗前后血清VEGF的动态变化。结果与正常对照组比较,CAD患者术后24 h内血清VEGF水平明显升高(P<0.01),血运重建完全患者术后3 d VEGF水平显著降低,不完全血运重建患者术后7 d VEGF水平仍高于正常(P<0.01)。结论 VEGF的表达与心肌缺血程度相关,监测其动态变化有助于诊断CAD病变程度和观察介入治疗的效果,对冠心病PCI疗法的实行和预后有指导意义。更多还原

【Abstract】 Objective To detect the dynamic changes of VEGF in CAD patients before and after PCI, and discuss its relationship with the diagnosis, treatment and prognosis of the patients. Methods ELISA essay was used to detect the serum VEGF in CAD patients before and after PCI. Results Compared with the control group, serum VEGF levels in CAD patients significantly increased(P<0.01) within 24 h after the operation, VEGF levels in patients with total revascularization decreased significantly 3 d after PCI, while VEGF levels were still higher than normal(P<0.01) 7 d postoperative in patients with incomplete revascularization. Conclusion The expressions of VEGF were related to the extent of myocardial ischemia, monitoring of their dynamics could help diagnose the severity of CAD and observe the effect of PCI, which had guiding significance on practice and prognosis of PCI therapy on CAD.更多还原