【摘要】 提出了一种高效合成3’,5’-O-二乙酰基-4-硫胸腺嘧啶核苷的方法,该方法具有反应时间短、操作简便等优点,目标产物产率可达93.9%以上。以二氧六环做溶剂,反应温度102℃,乙酰化胸腺嘧啶核苷与P2S5的摩尔比为1∶1.2,微波功率700W辐射8分钟,即可高收率得到3’,5’-O-二乙酰基-4-硫胸腺嘧啶核苷。更多还原

【Abstract】 A highly efficient methodology of synthesis of 3′,5′-O-diacetyl-4-thiothymidine up to 93.3%yield was reported in this paper.The synthetic methodology had advantages such as a concision and short reaction time.3′,5′-O-Diacetyl-4-thiothymidine was synthesized at 102℃ in dioxane with 1.0∶1.2 ratio of protected thymidine and P2S5 under microwave irradiation for 8 min.更多还原