【摘要】 以2-氨基-5-氟苯甲酸为原料,经溴代、重氮化、还原合成中间体3-溴-5-氟苯甲酸,再以甲苯为溶剂,氯化亚砜氯化后通入氨气,所得酰胺和五氧化二磷共热蒸馏得标题化合物,总收率53.4%(以2-氨基-5-氟苯甲酸计)。更多还原

【Abstract】 3-Bromo-5-fluorobenzonitrile was synthesized from2-amino-5-fluorobenzoic acid.It started from bromination using 1,3-dibromo-5,5-dimethylhydantoin,dizotization by sodium nitrite and reduction with ethanol to give 3-bromo-5-fluorobenzonic acid as the key intermediate.Then,the process was followed by chlorination with thionyl chloride,ammonization with ammonia gas in the present of toluene and distillation with phosphorus pentoxide.The overall yield was53.4%( based on 2-amino-5-fluorobenzoic acid).更多还原